Prachi Desai is one of the first of Ekta Kapoor’s discoveries, who has managed to make a smooth transition from television to cinema. Much of the credit goes to Ekta and her family, who adore Prachi and have tried their best to push her. After creating a stir nationwide as Bani Walia in the teleserial ‘Kasamh Se’.
Prachi's first film was Rock On!! (2008), where she played the wife of Farhan Akhtar. The film was an average box-office commercial but was critically appreciated, even getting the National Film Award for Best Feature Film in Hindi. She got several nominations as debutant including the Filmfare Award. She even won Ananadalok Awards as Best Actress (Hindi).
Her next film was Life Partner (2009). The film didn't do well at the box office but her performance was again much appreciated.
In July 2010, she appeared in Once Upon a Time in Mumbaai with Ajay Devgan, Emraan Hashmi and Kangna Ranaut. The film proved to be a big box office success and critically praised. Prachi's performance earned her many awards including IIFA Awards, Stardust Awards, Zee Cine Awards, Apsara Film & Television Producers Guild Awards and many more and nominations for supporting role at Filmfare Awards and Star Screen Awards.
She later starred in filsm like 'Teri Meri Kahani', 'Bol Bachchan' and 'I, Me Aur Main'.